After the capture of Caillaria on October 15, 1912, the Greek army sought to strengthen the defence on the left flank of the Thessaly Army and the conservative conquest of further territories in Western Macedonia. As early as October 15, the Cavalry Brigade, during a reconnaissance mission, had observed the presence of a strong Ottoman force at Nalbankioi (now Perdikkas), consisting of about 1,000 infantry, 50 cavalry, 200 irregulars and 6 artillery pieces.

During the night between the 15th and 16th of October 1912, the General Headquarters in Kozani issued an order for the advance of the V Division towards Nalbankioi. Because of the information that had been passed on from the Cavalry Brigade, the attack towards Nalbankioi was organized in three columns: The central column would proceed in a frontal attack, while the flank columns would operate in support from the villages of Elos (now Drosero) to the west, and Ineli (now Anatoliko) to the east of Nalbankioi.

On October 15, 1912, the Greek army occupied Kaillaria and subsequently engaged in the process of strengthening its defensive positions while advancing in a cautious manner into Western Macedonia. Aware of the presence of a substantial Ottoman military force at Nalbankioi (now Perdikkas) and of the need to gain control of this strategic location, the General Headquarters promptly directed the V Division to launch an offensive. The attack, which occurred on October 16, was structured in a triangular formation comprising a central column and two flank columns. At the outset of the engagement, the central phalanx came under intense fire. However, with the subsequent arrival of the side phalanxes, the Ottomans were encircled and compelled to withdraw. The Greek forces pursued their adversaries to the village of Filotas, seizing approximately 200 Ottoman combatants. Despite this notable triumph, the Greek forces sustained considerable losses, with 57 fatalities and 339 injuries.

A total of 57 Greek officers and soldiers perished in the Battle of Nalbankioi, while 339 others sustained injuries. The precise number of Ottoman casualties remains uncertain, but it is probable that they were significant, given that approximately 200 were taken prisoner.